Progesterone Receptor

NR3C3

Progesterone Receptor

Related Products

Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Progesterone Receptor Related Products (159)
Recombinant Proteins (1)
Antibodies (2)

By Effects:	Inhibitors (11) Agonists (76) Ligands (5) Antagonists (22) Activators (10) Modulators (10)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W703425

17α-Ethynyl-19-nor-Δ-5(6)-androsten-17β-ol-3-one	Agonist
17α-Ethynyl-19-nor-Δ-5(6)-androsten-17β-ol-3-one (delta-5(6)-Norethindrone), an impurity of Norethindrone, is an anabolic agent. Norethindrone is a progestin athat can be used for endometriosis research.

HY-B0554S1

Norethindrone-¹³C₂	Agonist
Norethindrone-¹³C₂ (Norethisterone-¹³C₂) is the ¹³C labeled Norethindrone (HY-B0554). Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-16508S1

Ulipristal acetate-d₃	Antagonist
Ulipristal acetate-d₃ (CDB-2914-d₃) is deuterium labeled Ulipristal acetate. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma.

HY-106140A

Asoprisnil ecamate	Modulator
Asoprisnil ecamate (J 956) is an orally active antiprogestin, and can be used for contraception.

HY-168759

11α-Hydroxytestosterone	Ligand
11α-Hydroxytestosterone is a deriviative of Hydrocortisone (HY-N0583), with the relative binding affinity to progesterone receptor of 9% (comparing to R5020 (HY-119384) 100%). 11α-Hydroxytestosterone inhibits the growth and differentiation of human decidual cells in culture.

HY-106299

Lilopristone	Antagonist
Lilopristone (ZK98734) is a progesterone antagonist with a potential to induce menstruation, inhibit nidation, and terminate pregnancy. Lilopristone blocks progesterone action at the endometrium as well as decreases progesterone bioavailability, and can be utilized in antifertility research.

HY-105177

ORG 33628	Modulator
ORG 33628 is a potent and selective progesterone receptor modulator. ORG 33628 shows anti-progestational and anti-glucocorticoid activity. ORG 33628 shows ovulation-inhibitory activity. ORG 33628 has the potential for the research of breast and endometrium.

HY-W011890R

Cridanimod (Standard)	Activator
Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer.

HY-105634AR

Nomegestrol acetate (Standard)	Agonist
Nomegestrol acetate (Standard) is the analytical standard of Nomegestrol acetate. This product is intended for research and analytical applications. Nomegestrol acetate is an orally active, highly selective progestogen and a progesterone receptor complete agonist. Nomegestrol acetate inhibits ovulation. Nomegestrol acetate is also effective in inhibiting the proliferation of human endometrial cancer RL95-2 cells in vitro and in vivo. Nomegestrol acetate can be used in cancer (especially endometrial cancer) and contraceptive studies.

HY-139244S

Norgestimate-d₆
Norgestimate-d₆ is the deuterium labeled Norgestimate. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive. Norgestimate-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B1089R

Ethynodiol diacetate (Standard)	Agonist
Ethynodiol diacetate (Standard) is the analytical standard of Ethynodiol diacetate. This product is intended for research and analytical applications. Ethynodiol diacetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0084S3

Dienogest-¹³C₂,¹⁵N	Agonist
Dienogest-¹³C₂,¹⁵N (STS 557-¹³C₂,¹⁵N) is ¹³C- and ¹⁵N-labeled Dienogest (HY-B0084).

HY-17375R

Allylestrenol (Standard)
Allylestrenol (Standard) is the analytical standard of Allylestrenol. This product is intended for research and analytical applications. Allylestrenol is an orally active synthetic anti-androgen sexualsteroid. Allylestrenol can prevent miscarriage in vivo. Allylestrenol significantly affects testosterone progesterone level in rat model. Allylestrenol can reduce ventral prostate weight in rat model.

HY-106827S1

Trimegestone-¹³C,d₃	Inhibitor
Trimegestone-¹³C,d₃ is ¹³C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC₅₀ value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC₅₀=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes.

HY-B1834R

Megestrol (Standard)	Agonist
Megestrol (Standard) is the analytical standard of Megestrol. This product is intended for research and analytical applications. Megestrol is an orally active glucocorticoid and progesterone receptor agonist. Megestrol can alleviate anorexia, cachexia or unexplained significant weight loss associated with acquired immunodeficiency syndrome (AIDS). Megestrol may cause manifestations similar to those of glucocorticoids and increase the risk of mental disorders.

HY-105820

Algestone	Agonist
Algestone is a progestin that exhibits hormonal contraceptive effects.

HY-14959S

Ulipristal-d₃	Modulator
Ulipristal-d₃ (CDB-3236-d₃) is deuterium labeled Ulipristal. Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system.

HY-B0521R

Altrenogest (Standard)	Agonist
Altrenogest (Standard) is the analytical standard of Altrenogest. This product is intended for research and analytical applications. Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone.

HY-U00091

Gestonorone Capronate
Gestonorone Capronate is a progestin for the treatment of benign prostatic hypertrophy and endometrial cancer.

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Progesterone Receptor

Progesterone Receptor

Progesterone Receptor Related Products (159)

Recombinant Proteins (1)

Antibodies (2)

Progesterone Receptor Related Products (159):